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Testosterone, the most important sexhormone in men, is testosterone. It has positive effects on almost all sexual functions. It is also important for bone and muscle formation, fat and sugar metabolism, blood formation, and hair growth. The protective role of testosterone on the heart and blood vessels is very important. Numerous studies over time have shown that testosterone levels correlate positively with life expectancy.

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Testosterone

Testes produce 90% of the male sex hormone testosterone and adrenal glands 10%. The starting material for hormone production in both men and women is cholesterol, from which progestins (pregnenolone) and dehydroepiandrosterone (DHEA) are subsequently formed. The adrenal cortex and testes are the main production sites for testosterone. Testosterone then enters the bloodstream. The blood vessels carry testosterone to the target organs/tissues. It exerts its organ-specific effects directly as testosterone, or after conversion (metabolization) to dihydrotestosterone and estrogens (17 beta-estradiol). The biological functions and enzyme patterns of the individual organs/tissues will determine whether testosterone is further metabolized in their bodies to 17 beta-estradiol or dihydrotestosterone.

Testosterone’s Biological Functions

The impact of testosterone on men’s sexual functions is decisive. These are the main mechanisms that testosterone uses to influence sexual function. The brain produces the neurotransmitters that are responsible for erection. This is influenced by testosterone and, to a lesser extent, dihydrotestosterone. These are neurotransmitters whose formation and release in the brain lead to the initiation of pleasure sensation and the initiation of the biological/biochemical processes for erection induction.

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Dihydrotestosterone, or testosterone (DHT), controls our brain drive behavior and is responsible for male aggression and drive hormones. The complete cessation or absence of male drive behavior can be caused by hormone deprivation. This can happen by removing testicular tissue (castration), or medication (LHRH analogs). While testosterone levels in women are lower than those in men, testosterone is still a key pleasure hormone for women. Women have a lower libido. A testosterone deficiency is often found in women with libido problems (sexual aversion). These women can benefit from the Intrinsa testosterone patch.

Testosterone, Sexual Organs and Testosterone

After its conversion into dihydrotestosterone in the embryo, testosterone causes the growth and development of the external sex (penis, scrotum), and internal sex (prostate, seminal vasicles) already in the embryo. Later in life, testosterone (or its metabolite dihydrotestosterone) is responsible to the growth of the penis or scrotum as well as the formation of pubic hairs during puberty. The dihydrotestosterone effect (DHT) also makes the male sex organs, the prostate and the seminal vesicles, grow to adult sizes.

Fertility and Testosterone

The hormones FSH, LH and testosterone/dihydrotestosterone are responsible for spermiogenesis (synthesis of sperm) and their vitality. DHT and testosterone are especially responsible for maturing sperm synthesis that is induced by FSH. This is 10 times more than what is required to produce testosterone serum.

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Testosterone and Muscle Metabolism

Together with IGF-1, testosterone is responsible for protein synthesis and muscle development. Direct stimulation of muscle protein synthesis by testosterone can lead to an increase in strength and size, particularly if affected muscle groups are also trained through other sports. Anabolic steroids and testosterone derivatives have been the most popular doping hormones among competitive athletes to this day. Additionally, testosterone and DHT directly affect the neuromuscular transmissions of excitation (transmissions of nerve signals to muscle fibers), which results in activation of respective muscles.

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